Emil  abdebhaldeh



' EMIL'ABDERHALDEN, OF HALLE, GERMANY.

snnuivr THERAPY.

Specification of Letters Patent. Patented Aug, 29, 1916.

No Drawing. Original application filed August 27, 1915, Serial No. 47,692. Divided and this application filed December 1, 1915. Serial No. 64,527.

To all "whom, it may concern Be it known that I, EMIL ABDERHALDEN,

' professor of physiology, doctor of medicine,

subject of the German Empire, residing at Halle, Germany, have invented new and useful Improvements in Serum Therapy, of which the following is a specification.

This invention relates to methods for determining the particular variety of cancer in an animal affected therewith and more particularly to a method for ascertaining whether or not the cancer of a cancer carrier is biologically related to cancer of known variety, or to an antiserum which has been produced by the known variety of cancer.

This application is a division of my application, Serial Number 17,692' filed August 27, 1915. 1

In my application, Serial Number 28,195 filed May 14, 1915, I have described new kinds of sera containing protective ferments which have an unusuallygpowerful lysing action on cancerous tissueu'p'lhesesera are 7 obtained by injecting-"tancerl albumin into an animal, withdrawing serum therefrom before the protective fermentsfirst formed have disappeared, injecting said serum into a fresh animal to produce a serum of angmented strength in protective ferments', and continuing the transference-i of serum through a series of animals until a serum of the-desired potency is secured. The potentiated serum so obtained has the valuable manifests distinct curative efi'ects, as has been demonstrated by many clinical tests.

This potentiated serum appears to have a i specific destructive (lysing) action'only on the particular-protein or protein derivative which originally induced its formation.

I Thus ifcancer tissue or any other kind of tissue, or any. peptonemixture. obtained from the protein ofsuch tissues, is introduced parenterally- (i. e. subcutaneously or intravenously) into animals or human beings, there appear in the serum of the animal or human being, protective ferments which have a selective action upon the partlcular. albumins or peptones introduced.

'Before using the potentiated serum in the treatment of cancer it is therefore necessary to make sure that the serum to be used corresponds to the particular variety of the albuanti-cancer serum be brought in contact with. -the part cular variety of cancer albumin which had been used in its preparation a re action will occur which is evidenced by the formation ofdialyzable substances. Based on these observations, the following method of verifying the biological relationship between a certain anti-cancer serum and the serum of a cancer carrier has been developed: An anti-cancer serum is allowed to react on a certain cancerous tissue which is supposed to be related to said serum, and 3 according to well known methods it is determined whether dialyzablesubstances are formed or not. Then the serum of the cancer carrier is also allowed to react on another portion of the same cancer tissue. If the results are" identical in both cases, that is, if

.both seracause cleavage, the antiserum is considered to conform to the serum of the v cancer carrier.

property that ifinjected into human beings; suffering with carcinoma, for instance, it

Treatment of the cancer cawimw after it has been determined'that the serurfl of the cancer carrier conforms to a certain anti- The properly selected-antiserum manifests distinct curative efiects in the cancer carrier, and complete disappearance of cancers of various types has been observed.

'1 claim:

A method of verifying the biological 'relationship between an anti-cancer serum and the serum of a cancer carrier which consists 'incausmg said anti-cancer serum to react on two sent on substanti ally In testimony whereof I have hereuntc set my hand in the presence of two subscribing witnesses.

EMIL ABDERHALDEN.

Witnesses:

RUDOLPH FRIOKE, WM. P. :KENT. 

